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Article

ZIC2 promotes cancer stem cell traits via up-regulating OCT4 expression in lung adenocarcinoma cells

1 Jan 2020

Abstract excerpt

Background: Accumulating evidence has revealed the importance of cancer stem cells (CSCs) in self-renewal and chemoresistance. Previous studies reported high expression of ZIC2 was closely associated with tumorigenesis and CSC traits. However, the role of ZIC2 as a crucial factor for regulating CSC properties in lung adenocarcinoma (LAC) remains elusive. Methods: RT-PCR and WB assay were employed to assess ZIC2...

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PMID: 32922547
DOI: 10.7150/jca.44367

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