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Article

Noninvasive saliva-based EGFR gene mutation detection in patients with lung cancer.

American journal of respiratory and critical care medicine - 15 Nov 2014

Wei Fang, Lin Chien-Chung, Joon Aron, Feng Ziding, Troche Gabriel, Lira Maruja E, Chia David, Mao Mao, Ho Chung-Liang, Su Wu-Chou, Wong David T W

Abstract excerpt

RATIONALE: Constitutive activation of the epidermal growth factor receptor (EGFR) is prevalent in epithelial cancers, particularly in non-small cell lung carcinoma (NSCLC). Mutations identified in EGFR predict the sensitivity to EGFR-targeted therapy. Detection of these mutations is mainly based on tissue biopsy, which is invasive, expensive, and time consuming. OBJECTIVES: Noninvasive, real-time, inexpensive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25317990
DOI: 10.1164/rccm.201406-1003OC
PMCID: PMC5447327

Genes

EGFR

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