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rs2072580T>A Polymorphism in the Overlapping Promoter Regions of the SART3 and ISCU Genes Associated with the Risk of Breast Cancer.

Bulletin of experimental biology and medicine - 1 May 2020

Degtyareva A O, Leberfarb E Y, Efimova E G, Brusentsov I I, Usova A V, Lushnikova E L, Merkulova T I

Abstract excerpt

We analyzed association of potentially regulatory polymorphisms (rs590352, rs11542583, rs3829202, rs207258, and rs4796672) with breast cancer. A significant association was found between this disease and rs2072580T>A (p=0.001) located in the overlapping promoter regions of the SART3 and ISCU genes. In women with AA and AT genotypes, the risk of breast cancer is higher by 6.7 times (p=0.001) and 12 times...

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PMID: 32495170
DOI: 10.1007/s10517-020-04829-2

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