Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts.

doi:10.1016/j.celrep.2020.107716

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Article

Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts.

Cell reports - 2 Jun 2020

Huckins Laura M, Chatzinakos Chris, Breen Michael S, Hartmann Jakob, Klengel Torsten, da Silva Almeida Ana C, Dobbyn Amanda, Girdhar Kiran, Hoffman Gabriel E, Klengel Claudia, Logue Mark W, Lori Adriana, Maihofer Adam X, Morrison Filomene G, Nguyen Hoang T, Park Yongjin, Ruderfer Douglas, Sloofman Laura G, van Rooij Sanne J H, Baker Dewleen G, Chen Chia-Yen, Cox Nancy, Duncan Laramie E, Geyer Mark A, Glatt Stephen J, Im Hae Kyung, Risbrough Victoria B, Smoller Jordan W, Stein Dan J, Yehuda Rachel, Liberzon Israel, Koenen Karestan C, Jovanovic Tanja, Kellis Manolis, Miller Mark W, Bacanu Silviu-Alin, Nievergelt Caroline M, Buxbaum Joseph D, Sklar Pamela, Ressler Kerry J, Stahl Eli A, Daskalakis Nikolaos P

Abstract excerpt

To reveal post-traumatic stress disorder (PTSD) genetic risk influences on tissue-specific gene expression, we use brain and non-brain transcriptomic imputation. We impute genetically regulated gene expression (GReX) in 29,539 PTSD cases and 166,145 controls from 70 ancestry-specific cohorts and identify 18 significant GReX-PTSD associations corresponding to specific tissue-gene pairs. The results suggest...

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PMID: 32492425
DOI: 10.1016/j.celrep.2020.107716
PMCID: PMC7359754

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