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Toxoplasma gondii Chinese I genotype Wh6 strain infection induces tau phosphorylation via activating GSK3β and causes hippocampal neuron apoptosis.

Acta tropica - 1 Oct 2020

Tao Qing, Wang Xianhe, Liu Lei, Ji Yongsheng, Luo Qingli, Du Jian, Yu Li, Shen Jilong, Chu Deyong

Abstract excerpt

Toxoplasma gondii (T. gondii) is a neurophilic and intracellular parasite that can affect plenty of vertebrate animals, including humans. Recent researches indicate that T. gondii infection is associated with neurodegenerative diseases such as Alzheimer's disease(AD). In addition, tau hyper-phosphorylation is a crucial event leading to the formation of nerve fiber tangles in AD. Despite the efforts to understand...

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PMID: 32492398
DOI: 10.1016/j.actatropica.2020.105560

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