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Diabetic Retinopathy and Damage to Mitochondrial Structure and Transport Machinery

15 Oct 2011

Abstract excerpt

PURPOSE: Mitochondrial function is controlled by membrane structure. In diabetes, retinal mitochondria are dysfunctional, and reversal of hyperglycemia fails to inhibit such changes. The goal of this study was to use anatomic and molecular biologic techniques to investigate the effect of diabetes on mitochondrial membrane structure. METHODS: Wistar rats were maintained in poor glycemic control (PC; GHb 11.2%) or...

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PMID: 22003103
DOI: 10.1167/iovs.11-8045

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