Circulating tumor cells for comprehensive and multiregional non-invasive genetic characterization of multiple myeloma.

doi:10.1038/s41375-020-0883-0

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Article

Circulating tumor cells for comprehensive and multiregional non-invasive genetic characterization of multiple myeloma.

Leukemia - 1 Nov 2020

Garcés Juan-José, Bretones Gabriel, Burgos Leire, Valdes-Mas Rafael, Puig Noemi, Cedena Maria-Teresa, Alignani Diego, Rodriguez Idoia, Puente Diana Álvarez, Álvarez Miguel-García, Goicoechea Ibai, Rodriguez Sara, Calasanz Maria-Jose, Agirre Xabier, Flores-Montero Juan, Sanoja-Flores Luzalba, Rodriguez-Otero Paula, Rios Rafael, Martinez-Lopez Joaquin, Millacoy Pamela, Palomera Luis, Del Orbe Rafael, Pérez-Montaña Albert, El Omri Halima, Prosper Felipe, Mateos Maria-Victoria, Rosiñol Laura, Blade Joan, Lahuerta Juan-Jose, Orfao Alberto, Lopez-Otin Carlos, San Miguel Jesus F, Paiva Bruno

Abstract excerpt

Multiple myeloma (MM) patients undergo repetitive bone marrow (BM) aspirates for genetic characterization. Circulating tumor cells (CTCs) are detectable in peripheral blood (PB) of virtually all MM cases and are prognostic, but their applicability for noninvasive screening has been poorly investigated. Here, we used next-generation flow (NGF) cytometry to isolate matched CTCs and BM tumor cells from 53 patients...

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Identifiers

PMID: 32475991
DOI: 10.1038/s41375-020-0883-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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