Article
Genetic variants in the MTHFR are not associated with fatty liver disease.
Liver international : official journal of the International Association for the Study of the Liver - 1 Aug 2020
De Vincentis Antonio, Mancina Rosellina Margherita, Pihlajamäki Jussi, Männistö Ville, Petta Salvatore, Dongiovanni Paola, Fracanzani Anna Ludovica, Valenti Luca, Tavaglione Federica, Romeo Stefano, Vespasiani-Gentilucci Umberto
Abstract excerpt
The common missense sequence variants of methylenetetrahydrofolate reductase (MTHFR), rs1801131 (c.A1298C) and rs1801133 (c.C677T), favour the development of hyperhomocysteinemia and diminished DNA methylation. Previous studies, carried out in small series and with suboptimal characterization of the hepatic phenotype, tested the association of these genetic variants with fatty liver disease (FLD), with...
Read the complete abstract on PubMed