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Article

Adenosine receptor expression in rheumatoid synovium: a basis for methotrexate action.

Arthritis research & therapy - 8 Jun 2012

Stamp Lisa K, Hazlett Jody, Roberts Rebecca L, Frampton Christopher, Highton John, Hessian Paul A

Abstract excerpt

INTRODUCTION: Methotrexate (MTX) exerts at least part of its anti-inflammatory effects through adenosine receptors (ADOR). The aims of this study were to determine the expression of all four adenosine receptor genes (ADORA1, ADORA2A, ADORA2B, ADORA3 and ADORA3variant) in rheumatoid synovial tissue and any influence of MTX exposure on this expression. Furthermore, we investigated whether polymorphisms within...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22682496
DOI: 10.1186/ar3871
PMCID: PMC3446521

Genes

ADORA3
ADORA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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