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Article

Prophylactic treatment of rapamycin ameliorates naturally developing and episode -induced heterotopic ossification in mice expressing human mutant ACVR1.

Orphanet journal of rare diseases - 24 May 2020

Maekawa Hirotsugu, Kawai Shunsuke, Nishio Megumi, Nagata Sanae, Jin Yonghui, Yoshitomi Hiroyuki, Matsuda Shuichi, Toguchida Junya

Abstract excerpt

BACKGROUND: Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant disease characterized by heterotopic ossification (HO) in soft tissues and caused by a mutation of the ACVR1A/ALK2 gene. Activin-A is a key molecule for initiating the process of HO via the activation of mTOR, while rapamycin, an mTOR inhibitor, effectively inhibits the Activin-A-induced HO. However, few reports have verified the...

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Identifiers

PMID: 32448372
DOI: 10.1186/s13023-020-01406-8
PMCID: PMC7245788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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