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Article

Parameter subset reduction for patient-specific modelling of arrhythmogenic cardiomyopathy-related mutation carriers in the CircAdapt model.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences - 12 Jun 2020

van Osta Nick, Lyon Aurore, Kirkels Feddo, Koopsen Tijmen, van Loon Tim, Cramer Maarten J, Teske Arco J, Delhaas Tammo, Huberts Wouter, Lumens Joost

Abstract excerpt

Arrhythmogenic cardiomyopathy (AC) is an inherited cardiac disease, clinically characterized by life-threatening ventricular arrhythmias and progressive cardiac dysfunction. Patient-specific computational models could help understand the disease progression and may help in clinical decision-making. We propose an inverse modelling approach using the CircAdapt model to estimate patient-specific regional...

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Identifiers

PMID: 32448061
DOI: 10.1098/rsta.2019.0347
PMCID: PMC7287326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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