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ATP7B R778L mutant hepatocytes resist copper toxicity by activating autophagy and inhibiting necroptosis

16 Sept 2023

Abstract excerpt

Abstract Wilson’s disease (WD) is an inherited disease characterized by copper metabolism disorder caused by mutations in the adenosine triphosphatase copper transporting β gene (ATP7B). Currently, WD cell and animal model targeting the most common R778L mutation in Asia is lacking. In addition, the mechanisms by which hepatocytes resist copper toxicity remain to be further elucidated. In this study, we aimed to...

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PMID: 37717021
DOI: 10.1038/s41420-023-01641-5

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