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Article

Distinct genetic architecture of coronary heart disease in dyslipidemia patients.

BMC medical genomics - 12 May 2026

Huang Man, Song Xiuli, Zhou Shuni, Zhang Haiyan, He Lijuan, Chen Yanghui, Chen Guangzhi, Ding Hu, Jiang Jiangang, Wang Yan, Wang Dao Wen, Sun Yang, Wang Hong

Abstract excerpt

BACKGROUND: Mutations of LDLR, APOB and PCSK9 have been well-established to cause hypercholesterolemia while the pathogenic effects of LPL has been confirmed by cohorts and functional studies in hypertriglyceridemia. However, these mutations do not fully account for all dyslipidemia, and it remains unexplained why some patients with dyslipidemia develop coronary heart disease (CHD) while others do not. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42121140
DOI: 10.1186/s12920-026-02388-5
PMCID: PMC13344052

Genes

LDLR
LPL
LPP
APOA5
APOB
ATP1A4
COL24A1
COL5A1
COL6A2
COL6A6
PCSK9
SLC3A1
SLC7A9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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