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Article

Global quantification of tissue dynamics in the developing mouse kidney.

Developmental cell - 28 Apr 2014

Short Kieran M, Combes Alexander N, Lefevre James, Ju Adler L, Georgas Kylie M, Lamberton Timothy, Cairncross Oliver, Rumballe Bree A, McMahon Andrew P, Hamilton Nicholas A, Smyth Ian M, Little Melissa H

Abstract excerpt

Although kidneys of equal size can vary 10-fold in nephron number at birth, discovering what regulates such variation has been hampered by a lack of quantitative parameters defining kidney development. Here we report a comprehensive, quantitative, multiscale analysis of mammalian kidney development in which we measure changes in cell number, compartment volumes, and cellular dynamics across the entirety of...

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Identifiers

PMID: 24780737
DOI: 10.1016/j.devcel.2014.02.017

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