Article
Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity.
eLife - 20 May 2020
Maitra Nairita, He Chong, Blank Heidi M, Tsuchiya Mitsuhiro, Schilling Birgit, Kaeberlein Matt, Aramayo Rodolfo, Kennedy Brian K, Polymenis Michael
Abstract excerpt
A long-standing problem is how cells that lack one of the highly similar ribosomal proteins (RPs) often display distinct phenotypes. Yeast and other organisms live longer when they lack specific ribosomal proteins, especially of the large 60S subunit of the ribosome. However, longevity is neither associated with the generation time of RP deletion mutants nor with bulk inhibition of protein synthesis. Here, we...
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