Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HPV16 E5 expression induces switching from FGFR2b to FGFR2c and epithelial‐mesenchymal transition

2 Dec 2014

Abstract excerpt

The E5 oncoprotein of the human papillomavirus type 16 (HPV16 E5) deregulates epithelial homeostasis through the modulation of receptor tyrosine kinases and their signaling. Accordingly, the fibroblast growth factor receptor 2b (FGFR2b/KGFR), epithelial splicing transcript variant of the FGFR2, is down-modulated by the viral protein expression, leading to impairment of keratinocyte differentiation. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fibroblast Growth Factor Research
Share to Neonatal Respiratory Health Research
Share to Proteoglycans and glycosaminoglycans research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25450802
DOI: 10.1002/ijc.29373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HPV16 E5 expression induces switching from FGFR2b to FGFR2c and epithelial‐mesenchymal transitionPMID 25450802Read ↗

Expression of the FGFR2 mesenchymal splicing variant in epithelial cells drives epithelial-mesenchymal transitionSemantic proximity Read ↗

HPV16 E5 deregulates the autophagic process in human keratinocytesSemantic proximity Read ↗

Role of PKCε in the epithelial-mesenchymal transition induced by FGFR2 isoform switchSemantic proximity Read ↗

Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycleSemantic proximity Read ↗

RNA splicing factors regulated by HPV16 during cervical tumour progressionSemantic proximity Read ↗

Cellular Functions of HPV16 E5 Oncoprotein during Oncogenic TransformationSemantic proximity Read ↗

The HPV-16 E5 protein represses expression of stress pathway genes XBP-1 and COX-2 in genital keratinocytes.Semantic proximity Read ↗

Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high-risk human papillomavirus oncogene.Semantic proximity Read ↗

The Human Papillomavirus Type 16 E5-Protein Modulates Ligand-Dependent Activation of the EGF Receptor Family in the Human Epithelial Cell Line HaCaTSemantic proximity Read ↗

HPV16 E6-mediated stabilization of ErbB2 in neoplastic transformation of human cervical keratinocytesSemantic proximity Read ↗

Splicing of HPV16 E6 promotes aggressive invasion in oropharyngeal cancer via endocytosis of E-cadherinSemantic proximity Read ↗

Human Papillomavirus Type 16 E5 Protein Induces Expression of Beta Interferon through Interferon Regulatory Factor 1 in Human KeratinocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.