Article
Genome-wide association studies reveal genetic variants in CTNND2 for high myopia in Singapore Chinese.
Ophthalmology - 1 Feb 2011
Li Yi-Ju, Goh Liang, Khor Chiea-Chuen, Fan Qiao, Yu Miao, Han Siyu, Sim Xueling, Ong Rick Twee-Hee, Wong Tien-Yin, Vithana Eranga Nishanthie, Yap Eric, Nakanishi Hideo, Matsuda Fumihiko, Ohno-Matsui Kyoko, Yoshimura Nagahisa, Seielstad Mark, Tai E-Shyong, Young Terri L, Saw Seang-Mei
Abstract excerpt
OBJECTIVE: To determine susceptibility genes for high myopia in Singaporean Chinese. DESIGN: A meta-analysis of 2 genome-wide association (GWA) datasets in Chinese and a follow-up replication cohort in Japanese. PARTICIPANTS AND CONTROLS: Two independent datasets of Singaporean Chinese individuals aged 10 to 12 years (Singapore Cohort Study of the Risk factors for Myopia [SCORM]: cases = 65, controls = 238) and...
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