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CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers

19 May 2020

Abstract excerpt

Abstract Many Alzheimer’s disease (AD) genes including Apolipoprotein E (APOE) are found to be expressed in blood-derived macrophages and thus may alter blood protein levels. We measured 91 neuro-proteins in plasma from 316 participants of the Rotterdam Study (incident AD = 161) using Proximity Extension Ligation assay. We studied the association of plasma proteins with AD in the overall sample and stratified by...

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PMID: 32427856
DOI: 10.1038/s41598-020-65038-5

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