Article
The Ancestral Caenorhabditis elegans Cuticle Suppresses rol-1.
G3 (Bethesda, Md.) - 7 Jul 2020
Noble Luke M, Miah Asif, Kaur Taniya, Rockman Matthew V
Abstract excerpt
Genetic background commonly modifies the effects of mutations. We discovered that worms mutant for the canonical rol-1 gene, identified by Brenner in 1974, do not roll in the genetic background of the wild strain CB4856. Using linkage mapping, association analysis and gene editing, we determined that N2 carries an insertion in the collagen gene col-182 that acts as a recessive enhancer of rol-1 rolling. From...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.