Article
Zika Virus Encoding Nonglycosylated Envelope Protein Is Attenuated and Defective in Neuroinvasion.
Journal of virology - 1 Dec 2017
Annamalai Arun S, Pattnaik Aryamav, Sahoo Bikash R, Muthukrishnan Ezhumalai, Natarajan Sathish Kumar, Steffen David, Vu Hiep L X, Delhon Gustavo, Osorio Fernando A, Petro Thomas M, Xiang Shi-Hua, Pattnaik Asit K
Abstract excerpt
Zika virus (ZIKV), a mosquito-transmitted flavivirus responsible for sporadic outbreaks of mild and febrile illness in Africa and Asia, reemerged in the last decade causing serious human diseases, including microcephaly, congenital malformations, and Guillain-Barré syndrome. Although genomic and phylogenetic analyses suggest that genetic evolution may have led to the enhanced virulence of ZIKV, experimental...
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