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The African Zika virus MR-766 is more virulent and causes more severe brain damage than current Asian lineage and Dengue virus

1 Jan 2017

Abstract excerpt

The Zika virus (ZIKV) has two lineages, Asian and African, and their impact on developing brains has not been compared. Dengue virus (DENV) is a close family member of ZIKV and co-circulates with ZIKV. Here, we performed intracerebral inoculation of embryonic mouse brains with dengue virus 2 (DENV2), and found that DENV2 is sufficient to cause smaller brain size due to increased cell death in neural progenitor...

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PMID: 28993398
DOI: 10.1242/dev.156752

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