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Article

Reduced Ebola vaccine responses in CMV+ young adults is associated with expansion of CD57+KLRG1+ T cells.

The Journal of experimental medicine - 6 Jul 2020

Bowyer Georgina, Sharpe Hannah, Venkatraman Navin, Ndiaye Pierre Birahim, Wade Djibril, Brenner Nicole, Mentzer Alex, Mair Catherine, Waterboer Tim, Lambe Teresa, Dieye Tandakha, Mboup Souleymane, Hill Adrian V S, Ewer Katie J

Abstract excerpt

CMV is associated with immunosenescence and reduced vaccine responses in the elderly (>70 yr). However, the impact of CMV in young adults is less clear. In this study, healthy UK and Senegalese adults aged 18-50 yr (average, 29 yr) were vaccinated with the Ebola vaccine candidate chimpanzee adenovirus type 3-vectored Ebola Zaire vaccine (ChAd3-EBO-Z) and boosted with modified vaccinia Ankara Ebola Zaire-vectored...

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Identifiers

PMID: 32413101
DOI: 10.1084/jem.20200004
PMCID: PMC7336307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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