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Article

<i>foxl3</i> , a sexual switch in germ cells, initiates two independent molecular pathways for commitment to oogenesis in medaka

14 May 2020

Abstract excerpt

Significance In teleost fish, unlike mammals, retinoic acid (RA) does not exert a conspicuous feminization effect of germ cells. Instead, in the teleost fish medaka, foxl3 serves as a germ cell-autonomous factor acting at the very beginning of the sexual fate decision. This study shows that foxl3 initiates oogenesis through two genetically independent pathways, meiosis and follicular development. One pathway,...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Reproductive biology and impacts on aquatic species

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Sperm and Testicular Function

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Identifiers

PMID: 32409601
DOI: 10.1073/pnas.1918556117

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