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Article

Retinoid Signaling Determines Germ Cell Fate in Mice

30 Mar 2006

Abstract excerpt

Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on molecular cues that have not been identified. We found that retinoic acid, produced by mesonephroi of both sexes, causes germ cells in the ovary to enter meiosis and initiate oogenesis. Meiosis is retarded in the fetal testis by the action of the retinoid-degrading enzyme CYP26B1, ultimately leading to spermatogenesis. In testes...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 16574820
DOI: 10.1126/science.1125691

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Retinoid Signaling Determines Germ Cell Fate in MicePMID 16574820Read ↗

Retinoic Acid and Germ Cell Development in the Ovary and TestisSemantic proximity Read ↗

Cyp26b1 expression in murine Sertoli cells is required to maintain male germ cells in an undifferentiated state during embryogenesis.Semantic proximity Read ↗

Cell cycle regulation for meiosis in mammalian germ cellsSemantic proximity Read ↗

Regulation of germ cell meiosis in the fetal ovarySemantic proximity Read ↗

Retinoic acid regulates sex-specific timing of meiotic initiation in miceSemantic proximity Read ↗

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Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovarySemantic proximity Read ↗

Instructing Mouse Germ Cells to Adopt a Female FateSemantic proximity Read ↗

Function of Retinoic Acid in Development of Male and Female GametesSemantic proximity Read ↗

Retinoic acid prevents germ cell mitotic arrest in mouse fetal testesSemantic proximity Read ↗

CYP26 Enzymes Are Necessary Within the Postnatal Seminiferous Epithelium for Normal Murine Spermatogenesis1Semantic proximity Read ↗

Sex determination in mammalian germ cellsSemantic proximity Read ↗

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