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<i>foxl3</i> is a germ cell–intrinsic factor involved in sperm-egg fate decision in medaka

11 Jun 2015

Abstract excerpt

Sex determination is an essential step in the commitment of a germ cell to a sperm or egg. However, the intrinsic factors that determine the sexual fate of vertebrate germ cells are unknown. Here, we show that foxl3, which is expressed in germ cells but not somatic cells in the gonad, is involved in sperm-egg fate decision in medaka fish. Adult XX medaka with disrupted foxl3 developed functional sperm in the...

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PMID: 26067255
DOI: 10.1126/science.aaa2657

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