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Retinoic acid and meiosis induction in adult versus embryonic gonads of medaka

28 Sept 2016

Abstract excerpt

In vertebrates, one of the first recognizable sex differences in embryos is the onset of meiosis, known to be regulated by retinoic acid (RA) in mammals. We investigated in medaka a possible meiotic function of RA during the embryonic sex determination (SD) period and in mature gonads. We found RA mediated transcriptional activation in germ cells of both sexes much earlier than the SD stage, however, no such...

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PMID: 27677591
DOI: 10.1038/srep34281

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