Article
Campylobacter jejuni type VI secretion system: roles in adaptation to deoxycholic acid, host cell adherence, invasion, and in vivo colonization.
PloS one - 1 Jan 2012
Lertpiriyapong Kvin, Gamazon Eric R, Feng Yan, Park Danny S, Pang Jassia, Botka Georgina, Graffam Michelle E, Ge Zhongming, Fox James G
Abstract excerpt
The recently identified type VI secretion system (T6SS) of proteobacteria has been shown to promote pathogenicity, competitive advantage over competing microorganisms, and adaptation to environmental perturbation. By detailed phenotypic characterization of loss-of-function mutants, in silico, in vitro and in vivo analyses, we provide evidence that the enteric pathogen, Campylobacter jejuni, possesses a functional...
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