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A rough Brucella mutant induced macrophage death depends on secretion activity of T4SS, but not on cellular Txnip- and Caspase-2-mediated signaling pathway.

Veterinary microbiology - 1 May 2020

Tian Mingxing, Yin Yi, Lian Zhengmin, Li Zichen, Song Meiying, Hu Hai, Guan Xiang, Ding Chan, Wang Shaohui, Li Tao, Qi Jingjing, Yu Shengqing

Abstract excerpt

Brucella is a facultative intracellular bacterium, dividing into smooth- and rough-type Brucella. Smooth-type Brucella can dissociate into rough mutants with cytotoxicity for macrophages during infection, which is critical for Brucella egress and dissemination. However, the mechanism of cytotoxicity infected by rough Brucella is incomplete. In this study, we verified that a rough-type Brucella (RB14 strain) was...

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PMID: 32402333
DOI: 10.1016/j.vetmic.2020.108648

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