Article
TceSR two-component regulatory system of Brucella melitensis 16M is involved in invasion, intracellular survival and regulated cytotoxicity for macrophages.
Letters in applied microbiology - 1 Jun 2015
Li Z, Fu Q, Wang Z, Li T, Zhang H, Guo F, Wang Y, Zhang J, Chen C
Abstract excerpt
The mechanisms of invasion and intracellular survival of Brucella are still poorly understood. Previous studies showed that the two-component regulatory systems (TCSs) play an important role in the intracellular survival of Brucella. To investigate if TCSs involve in the virulence and cytotoxicity of Brucella melitensis, we introduced a mutation into one of the TCSs in chromosome II in Br. melitensis 16M strain,...
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