The Brucella effector BspL targets the ER-associated degradation (ERAD) pathway and delays bacterial egress from infected cells

Abstract excerpt

Significance Intracellular bacterial pathogens rely on dedicated systems to inject effector proteins into host cells and cause disease. This is the case for Brucella abortus , which causes brucellosis, one of the world’s most prevalent zoonotic diseases. We have found one such effector that can control the intracellular fate of Brucella by hijacking the machinery of the endoplasmic reticulum generally used by our...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Brucella: diagnosis, epidemiology, treatment
• Share to Burkholderia infections and melioidosis
• Share to Endoplasmic Reticulum Stress and Disease