Article
Exon inclusion is dependent on predictable exonic splicing enhancers.
Molecular and cellular biology - 1 Aug 2005
Zhang Xiang H-F, Kangsamaksin Thaned, Chao Mann S P, Banerjee Joydeep K, Chasin Lawrence A
Abstract excerpt
We have previously formulated a list of approximately 2,000 RNA octamers as putative exonic splicing enhancers (PESEs) based on a statistical comparison of human exonic and nonexonic sequences (X. H. Zhang and L. A. Chasin, Genes Dev. 18:1241-1250, 2004). When inserted into a poorly spliced test exon, all eight tested octamers stimulated splicing, a result consistent with their identification as exonic splicing...
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