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Article

Protein exchange is reduced in calcium-independent epithelial junctions.

The Journal of cell biology - 1 Jun 2020

Bartle Emily I, Rao Tejeshwar C, Beggs Reena R, Dean William F, Urner Tara M, Kowalczyk Andrew P, Mattheyses Alexa L

Abstract excerpt

Desmosomes are cell-cell junctions that provide mechanical integrity to epithelial and cardiac tissues. Desmosomes have two distinct adhesive states, calcium-dependent and hyperadhesive, which balance tissue plasticity and strength. A highly ordered array of cadherins in the adhesive interface is hypothesized to drive hyperadhesion, but how desmosome structure confers adhesive state is still elusive. We employed...

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Source

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Identifiers

PMID: 32399559
DOI: 10.1083/jcb.201906153
PMCID: PMC7265307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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