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A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions

8 Jan 2011

Abstract excerpt

BACKGROUND: Cellular adhesion mediated by cardiac desmosomes is a prerequisite for proper electric propagation mediated by gap junctions in the myocardium. However, the molecular principles underlying this interdependence are not fully understood. OBJECTIVE: The purpose of this study was to determine potential causes of right ventricular conduction abnormalities in a patient with borderline diagnosis of...

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Identifiers

PMID: 21220045
DOI: 10.1016/j.hrthm.2011.01.010

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