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TET family regulates the embryonic pluripotency of porcine preimplantation embryos by maintaining the DNA methylation level of <i>NANOG</i>

13 May 2020

Abstract excerpt

The ten-eleven translocation (TET) family (TET1/2/3) initiates conversion of 5-methylcytosine to 5-hydroxymethylcytosine, thereby orchestrating the DNA demethylation process and changes in epigenetic marks during early embryogenesis. In this study, CRISPR/Cas9 technology and a TET-specific inhibitor were applied to elucidate the role of TET family in regulating pluripotency in preimplantation embryos using...

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PMID: 32397801
DOI: 10.1080/15592294.2020.1762392

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