Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A motor neuron protective role of miR-969 mediated by the transcription factor kay.

RNA biology - 1 Sept 2020

Zhang Xiao, Lyu Jialan, Jin Xiaoye, Yang Weiwei, Lou Ziwei, Xi Yongmei, Yang Xiaohang, Ge Wanzhong

Abstract excerpt

Maintenance of motor neuron structure and function is crucial in development and motor behaviour. However, the genetic regulatory mechanism of motor neuron function remains less well understood. In the present study, we identify a novel neuroprotective role of the microRNA miR-969 in Drosophila motor neurons. miR-969 is highly expressed in motor neurons. Loss of miR-969 results in early-onset and age-progressive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Cell Survival
Share to Drosophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique

Share to MicroRNAs

Share to Models, Biological

Share to Motor Neurons

Share to RNA Interference

Source

Open in PubMed Open full text

Identifiers

PMID: 32397794
DOI: 10.1080/15476286.2020.1757897
PMCID: PMC7549711

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A motor neuron protective role of miR-969 mediated by the transcription factor kay.PMID 32397794Read ↗

MotomiRs: miRNAs in Motor Neuron Function and DiseaseSemantic proximity Read ↗

miR-146a is a Pleiotropic Regulator of Motor Neuron DegenerationSemantic proximity Read ↗

The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila.Semantic proximity Read ↗

Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failureSemantic proximity Read ↗

Drosophila NMNAT Maintains Neural Integrity Independent of Its NAD Synthesis ActivitySemantic proximity Read ↗

Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondriaSemantic proximity Read ↗

MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron DegenerationSemantic proximity Read ↗

The conserved alternative splicing factor caper regulates neuromuscular phenotypes during development and aging.Semantic proximity Read ↗

Neurophysiological defects and neuronal gene deregulation in Drosophila mir-124 mutants.Semantic proximity Read ↗

The ALS-associated KIF5A P986L variant is not pathogenic for Drosophila motoneurons.Semantic proximity Read ↗

miRNA-based buffering of the cobblestone-lissencephaly-associated extracellular matrix receptor dystroglycan via its alternative 3'-UTR.Semantic proximity Read ↗

Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.