Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activin-inhibitory action on lactotrophs is decreased in lactotroph hyperplasia.

The Journal of endocrinology - 1 Feb 2020

Faraoni E Y, Abeledo Machado A I, Pérez P A, Marcial López C A, Camilletti M A, Peña-Zanoni M, Rulli S B, Gutiérrez S, Díaz-Torga G

Abstract excerpt

Among all the hormone-secreting pituitary tumours, prolactinomas are the most frequently found in the clinic. Since dopamine is the primary inhibitor of lactotroph function, dopamine agonists represent the first-line therapy. However, a subset of patients exhibits resistance to these drugs, and therefore, alternative treatments are desired. As activins inhibit prolactin gene expression through the inhibition of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activins
Share to Dopamine Agonists

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to MAP Kinase Signaling System

Share to Pituitary Gland

Share to Pituitary Neoplasms

Share to Sex Factors

Share to Transcription Factor Pit-1

Source

Identifiers

PMID: 32395971
DOI: 10.1530/JOE-19-0326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activin-inhibitory action on lactotrophs is decreased in lactotroph hyperplasia.PMID 32395971Read ↗

Short-term pharmacological suppression of the hyperprolactinemia of infertile hCG-overproducing female mice persistently restores their fertility.Semantic proximity Read ↗

Sex differences in the pituitary transforming growth factor-β1 system: studies in a model of resistant prolactinomas.Semantic proximity Read ↗

Prolactin: The New Biology of an Old HormoneSemantic proximity Read ↗

Autocrine/paracrine roles of extrapituitary growth hormone and prolactin in health and disease: An overviewSemantic proximity Read ↗

Galanin regulates prolactin release and lactotroph proliferation.Semantic proximity Read ↗

New concepts in prolactin biology.Semantic proximity Read ↗

Nuclear exclusion of menin drives functional MEN1 deficiency in non-MEN1 prolactinomas: mouse models and human biopsiesSemantic proximity Read ↗

Recent Findings on Hyperprolactinemia and its Pathological Implications: A Literature ReviewSemantic proximity Read ↗

Chronic high prolactin levels impact on gene expression at discrete hypothalamic nuclei involved in food intakeSemantic proximity Read ↗

Clinical, Pathological, and Molecular Factors of Aggressiveness in Lactotroph TumoursSemantic proximity Read ↗

Hyperprolactinemia in a male pituitary androgen receptor knockout mouse model is associated with a female-like pattern of lactotroph developmentSemantic proximity Read ↗

cAMP in the pituitary: an old messenger for multiple signals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.