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Article

Sex differences in the pituitary transforming growth factor-β1 system: studies in a model of resistant prolactinomas.

Endocrinology - 1 Nov 2013

Recouvreux M Victoria, Lapyckyj Lara, Camilletti M Andrea, Guida M Clara, Ornstein Ana, Rifkin Daniel B, Becu-Villalobos Damasia, Díaz-Torga Graciela

Abstract excerpt

Dopamine and estradiol interact in the regulation of lactotroph cell proliferation and prolactin secretion. Ablation of the dopamine D2 receptor gene (Drd2(-/-)) in mice leads to a sexually dimorphic phenotype of hyperprolactinemia and pituitary hyperplasia, which is stronger in females. TGF-β1 is a known inhibitor of lactotroph proliferation. TGF-β1 is regulated by dopamine and estradiol, and it is usually...

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Identifiers

PMID: 24008346
DOI: 10.1210/en.2013-1433
PMCID: PMC3800752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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