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Article

Short-term pharmacological suppression of the hyperprolactinemia of infertile hCG-overproducing female mice persistently restores their fertility.

Endocrinology - 1 Dec 2012

Ratner Laura D, Gonzalez Betina, Ahtiainen Petteri, Di Giorgio Noelia P, Poutanen Matti, Calandra Ricardo S, Huhtaniemi Ilpo T, Rulli Susana B

Abstract excerpt

Female infertility is often associated with deregulation of hormonal networks, and hyperprolactinemia is one of the most common endocrine disorders of the hypothalamic-pituitary axis affecting the reproductive functions. We have shown previously that transgenic female mice overexpressing human chorionic gonadotropin β-subunit (hCGβ+ mice), and producing elevated levels of bioactive LH/hCG, exhibit increased...

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Identifiers

PMID: 23117930
DOI: 10.1210/en.2012-1393
PMCID: PMC3544356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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