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Article

Requirement for a Complex of Wiskott-Aldrich Syndrome Protein (WASP) with WASP Interacting Protein in Podosome Formation in Macrophages

1 Mar 2007

Abstract excerpt

Chemotactic migration of macrophages is critical for the recruitment of leukocytes to inflamed tissues. Macrophages use a specialized adhesive structure called a podosome to migrate. Podosome formation requires the Wiskott-Aldrich syndrome protein (WASP), which is a product of the gene defective in an X-linked inherited immunodeficiency disorder, the Wiskott-Aldrich syndrome. Macrophages from WASP-deficient...

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PMID: 17312144
DOI: 10.4049/jimmunol.178.5.2987

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Requirement for a Complex of Wiskott-Aldrich Syndrome Protein (WASP) with WASP Interacting Protein in Podosome Formation in MacrophagesPMID 17312144Read ↗

WASP and WIP regulate podosomes in migrating leukocytesSemantic proximity Read ↗

The expression of Wiskott-Aldrich syndrome protein (WASP) is dependent on WASP-interacting protein (WIP)Semantic proximity Read ↗

WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1αSemantic proximity Read ↗

WIP, a protein associated with Wiskott–Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cellsSemantic proximity Read ↗

Wiskott–Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cellsSemantic proximity Read ↗

WIP null mice display a progressive immunological disorder that resembles Wiskott–Aldrich syndromeSemantic proximity Read ↗

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeletonSemantic proximity Read ↗

A Complex of Wiskott-Aldrich Syndrome Protein with Mammalian Verprolins Plays an Important Role in Monocyte ChemotaxisSemantic proximity Read ↗

Wiskott–Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activationSemantic proximity Read ↗

A partial down-regulation of WASP is sufficient to inhibit podosome formation in dendritic cells.Semantic proximity Read ↗

The Polarization Defect of Wiskott-Aldrich Syndrome Macrophages Is Linked to Dislocalization of the Arp2/3 ComplexSemantic proximity Read ↗

Mechanisms of WASp-mediated hematologic and immunologic disease.Semantic proximity Read ↗

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