Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting Cellular Metabolism in Acute Myeloid Leukemia and The Role of Patient Heterogeneity.

Cells - 7 May 2020

Grønningsæter Ida Sofie, Reikvam Håkon, Aasebø Elise, Bartaula-Brevik Sushma, Tvedt Tor Henrik, Bruserud Øystein, Hatfield Kimberley Joanne

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive blood cancer resulting in accumulation of immature, dysfunctional blood cells in the bone marrow. Changes in cell metabolism are features of many cancers, including AML and this may be exploited as a therapeutic target. In this study we investigated the in vitro antileukemic effects of seven metabolic inhibitors that target different metabolic pathways. The metabolic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bridged Bicyclo Compounds, Heterocyclic
Share to Cytarabine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Deoxyglucose

Share to fms-Like Tyrosine Kinase 3

Share to Gene Expression Regulation, Leukemic

Share to Karyotype

Share to Mesenchymal Stem Cells

Share to Nucleophosmin

Source

Open in PubMed Open full text

Identifiers

PMID: 32392896
DOI: 10.3390/cells9051155
PMCID: PMC7290417

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting Cellular Metabolism in Acute Myeloid Leukemia and The Role of Patient Heterogeneity.PMID 32392896Read ↗

Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemiaSemantic proximity Read ↗

Rationale for Targeting Deregulated Metabolic Pathways as a Therapeutic Strategy in Acute Myeloid LeukemiaSemantic proximity Read ↗

Targeting of cell metabolism in human acute myeloid leukemia--more than targeting of isocitrate dehydrogenase mutations and PI3K/AKT/mTOR signaling?Semantic proximity Read ↗

Metabolism in acute myeloid leukemia: mechanistic insights and therapeutic targetsSemantic proximity Read ↗

Metabolic drug survey highlights cancer cell dependencies and vulnerabilities.Semantic proximity Read ↗

Pharmacogenomics in acute myeloid leukemia.Semantic proximity Read ↗

Chemotherapeutic drugs elicit stemness and metabolic alteration to mediate acquired drug-resistant phenotype in acute myeloid leukemia cell lines.Semantic proximity Read ↗

The differential activation of metabolic pathways in leukemic cells depending on their genotype and micro-environmental stress.Semantic proximity Read ↗

Metabolomic profile of acute myeloid leukaemia parallels of prognosis and response to therapy.Semantic proximity Read ↗

Isocitrate dehydrogenase 2 mutation promotes cytarabine resistance in acute myeloid leukemia by Warburg effect.Semantic proximity Read ↗

NAD metabolism-related genes provide prognostic value and potential therapeutic insights for acute myeloid leukemiaSemantic proximity Read ↗

Plasma lipid levels predict chemotherapy response and survival in acute myeloid leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.