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Ebolavirus Glycoprotein Directs Fusion through NPC1 + Endolysosomes

15 Oct 2015

Abstract excerpt

Ebolavirus, a deadly hemorrhagic fever virus, was thought to enter cells through endolysosomes harboring its glycoprotein receptor, Niemann-Pick C1. However, an alternate model was recently proposed in which ebolavirus enters through a later NPC1-negative endosome that contains two-pore Ca(2+) channel 2 (TPC2), a newly identified ebolavirus entry factor. Here, using live cell imaging, we obtained evidence that in...

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PMID: 26468524
DOI: 10.1128/jvi.01828-15

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