Article
Chlorcyclizine Inhibits Viral Fusion of Hepatitis C Virus Entry by Directly Targeting HCV Envelope Glycoprotein 1.
Cell chemical biology - 16 Jul 2020
Hu Zongyi, Rolt Adam, Hu Xin, Ma Christopher D, Le Derek J, Park Seung Bum, Houghton Michael, Southall Noel, Anderson D Eric, Talley Daniel C, Lloyd John R, Marugan Juan C, Liang T Jake
Abstract excerpt
Chlorcyclizine (CCZ) is a potent hepatitis C virus (HCV) entry inhibitor, but its molecular mechanism is unknown. Here, we show that CCZ directly targets the fusion peptide of HCV E1 and interferes with the fusion process. Generation of CCZ resistance-associated substitutions of HCV in vitro revealed six missense mutations in the HCV E1 protein, five being in the putative fusion peptide. A viral fusion assay...
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