Article
WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2.
Cell death & disease - 7 May 2020
Carusone Teresa Maria, Cardiero Giovanna, Cerreta Mariangela, Mandrich Luigi, Moran Oscar, Porzio Elena, Catara Giuliana, Lacerra Giuseppina, Manco Giuseppe
Abstract excerpt
The activity of human paraoxonase 2 (PON2) is rapidly reduced in cells incubated with the bacterial quorormone 3-Oxo-dodecanoyl Homoserine Lactone (3OC12HSL), an observation that led to hypothesize a fast PON2 post-translational modification (PTM). Recently, we detected a 3OC12HSL-induced PTM in a cell-free system in which a crude extract from 3OC12HSL-treated HeLa cells was able to inactivate and ubiquitinate at...
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