Article
IL12B and IL17 genes polymorphisms associated with differential susceptibility to juvenile idiopathic arthritis and juvenile-onset systemic lupus erythematosus in Chinese children.
Medicine - 4 Aug 2023
Zhang Menglan, Peng Leiwen, Li Wensheng, Duan Yifei, Liu Xiaoqin, Chen Shasha, Deng Jiamin, Liu Xinle
Abstract excerpt
Genetic factors play a crucial role in the immune response of juvenile idiopathic arthritis (JIA) and juvenile-onset systemic lupus erythematosus (JSLE). This study aimed to investigate the association of IL12B (rs3212227, rs6887695) and IL17 (rs2275913, rs763780) gene polymorphisms with the susceptibility of JIA and JSLE in Chinese children. A total of 303 healthy controls and 304 patients including 160 JIA and...