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Article

Genetic Association Reveals Protection against Recurrence of Clostridium difficile Infection with Bezlotoxumab Treatment.

mSphere - 6 May 2020

Shen Judong, Mehrotra Devan V, Dorr Mary Beth, Zeng Zhen, Li Junhua, Xu Xun, Nickle David, Holzinger Emily R, Chhibber Aparna, Wilcox Mark H, Blanchard Rebecca L, Shaw Peter M

Abstract excerpt

Bezlotoxumab is a human monoclonal antibody against Clostridium difficile toxin B, indicated to prevent recurrence of C. difficile infection (rCDI) in high-risk adults receiving antibacterial treatment for CDI. An exploratory genome-wide association study investigated whether human genetic variation influences bezlotoxumab response. DNA from 704 participants who achieved initial clinical cure in the phase 3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32376702
DOI: 10.1128/mSphere.00232-20
PMCID: PMC7203456

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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