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Article

Whole-genome sequencing demonstrates that fidaxomicin is superior to vancomycin for preventing reinfection and relapse of infection with Clostridium difficile.

The Journal of infectious diseases - 1 May 2014

Eyre David W, Babakhani Farah, Griffiths David, Seddon Jaime, Del Ojo Elias Carlos, Gorbach Sherwood L, Peto Tim E A, Crook Derrick W, Walker A Sarah

Abstract excerpt

Whole-genome sequencing was used to determine whether the reductions in recurrence of Clostridium difficile infection observed with fidaxomicin in pivotal phase 3 trials occurred by preventing relapse of the same infection, by preventing reinfection with a new strain, or by preventing both outcomes. Paired isolates of C. difficile were available from 93 of 199 participants with recurrences (28 were treated with...

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Identifiers

PMID: 24218500
DOI: 10.1093/infdis/jit598
PMCID: PMC3982846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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