Article
The effects of knock-down resistance mutations and alternative splicing on voltage-gated sodium channels in Musca domestica and Drosophila melanogaster.
Insect biochemistry and molecular biology - 1 Jul 2020
Thompson Andrew J, Verdin Paul S, Burton Mark J, Davies T G Emyr, Williamson Martin S, Field Linda M, Baines Richard A, Mellor Ian R, Duce Ian R
Abstract excerpt
Voltage-gated sodium channels (VGSCs) are a major target site for the action of pyrethroid insecticides and resistance to pyrethroids has been ascribed to mutations in the VGSC gene. VGSCs in insects are encoded by only one gene and their structural and functional diversity results from posttranscriptional modification, particularly, alternative splicing. Using whole cell patch clamping of neurons from pyrethroid...
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