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Resistance to BRAF Inhibitors: EZH2 and Its Downstream Targets as Potential Therapeutic Options in Melanoma.

International journal of molecular sciences - 19 Jan 2023

Uebel Anne, Kewitz-Hempel Stefanie, Willscher Edith, Gebhardt Kathleen, Sunderkötter Cord, Gerloff Dennis

Abstract excerpt

Activating BRAF mutations occurs in 50-60% of malignant melanomas. Although initially treatable, the development of resistance to BRAF-targeted therapies (BRAFi) is a major challenge and limits their efficacy. We have previously shown that the BRAFV600E signaling pathway mediates the expression of EZH2, an epigenetic regulator related to melanoma progression and worse overall survival. Therefore, we wondered...

Topics

Humans
Cell Line, Tumor
Drug Resistance, Neoplasm
Enhancer of Zeste Homolog 2 Protein
Indoles
Melanoma
Mutation
Protein Kinase Inhibitors
Proto-Oncogene Proteins B-raf
Skin Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sulfonamides

Vemurafenib

Polo-Like Kinase 1

Source

Open in PubMed Open full text

Identifiers

PMID: 36768289
DOI: 10.3390/ijms24031963
PMCID: PMC9916477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Resistance to BRAF Inhibitors: EZH2 and Its Downstream Targets as Potential Therapeutic Options in Melanoma.PMID 36768289Read ↗

EZH2 Cooperates with DNA Methylation to Downregulate Key Tumor Suppressors and IFN Gene Signatures in Melanoma.Semantic proximity Read ↗

Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes.Semantic proximity Read ↗

Loss of HAT1 expression confers BRAFV600E inhibitor resistance to melanoma cells by activating MAPK signaling via IGF1RSemantic proximity Read ↗

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Divergent BRAF Inhibitor Resistance Mechanisms Revealed through Epigenetic Mapping.Semantic proximity Read ↗

The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.Semantic proximity Read ↗

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CRISPR Screens Identify Essential Cell Growth Mediators in BRAF Inhibitor-resistant Melanoma.Semantic proximity Read ↗

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Somatic Copy Number Amplification and Hyperactivating Somatic Mutations of EZH2 Correlate With DNA Methylation and Drive Epigenetic Silencing of Genes Involved in Tumor Suppression and Immune Responses in Melanoma.Semantic proximity Read ↗

BRAF inhibitor resistance confers increased sensitivity to mitotic inhibitorsSemantic proximity Read ↗

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