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Article

High MTHFR promoter methylation levels in men confer protection against ischemic stroke.

Bosnian journal of basic medical sciences - 2 Nov 2020

Xu Shan, Shi Qianping, Li Bo, Han Liyuan, Xu Guodong, Peng Xiaolin, Chen Hongen, Dai Shuhong, Ma Wancheng, Wang Changyi, Ma Jianping

Abstract excerpt

The MTHFR gene encodes methylenetetrahydrofolate reductase required for the metabolism of homocysteine (Hcy) - a previously reported independent risk factor for ischemic stroke (IS). In this study, we first aimed to clarify the association between DNA methylation levels in the MTHFR promoter and the risk of IS, followed by the analysis of potential interactions between environmental factors and DNA methylation...

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Identifiers

PMID: 32358951
DOI: 10.17305/bjbms.2020.4636
PMCID: PMC7664794

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