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Article

A possible synergistic effect of MTHFR C677T polymorphism on homocysteine level variations increased risk for ischemic stroke.

Medicine - 1 Dec 2017

Li Aifan, Shi Yunshu, Xu Liyan, Zhang Yuchao, Zhao Huiling, Li Qiangmin, Zhao Xingjuan, Cao Xinhui, Zheng Hong, He Ying

Abstract excerpt

BACKGROUND: Homocysteine (Hcy) plays an important role in vascular function and Hcy level contributes to pathogenesis of ischemic stroke (IS). MTHFR gene polymorphism may have effects on IS risks by influencing the Hcy metabolic pathway. In the present study, a case-control study was designed to evaluate the relationship among MTHFR C677Tpolymorphism, plasma Hcy level, and susceptibility of IS in Chinese...

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Identifiers

PMID: 29390494
DOI: 10.1097/MD.0000000000009300
PMCID: PMC5758196

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A possible synergistic effect of MTHFR C677T polymorphism on homocysteine level variations increased risk for ischemic stroke.PMID 29390494Read ↗

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